Subcortical white matter hyperintensities within the cholinergic pathways of Parkinson's disease patients according to cognitive status
Identifieur interne : 000028 ( Main/Exploration ); précédent : 000027; suivant : 000029Subcortical white matter hyperintensities within the cholinergic pathways of Parkinson's disease patients according to cognitive status
Auteurs : Jaeseung Shin [Corée du Sud] ; Sungeun Choi [Corée du Sud] ; Ji E. Lee [Corée du Sud] ; Hye Sun Lee [Corée du Sud] ; Young H. Sohn [Corée du Sud] ; Phil Hyu Lee [Corée du Sud, Niger]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2012-03.
Abstract
Background White matter hyperintensities (WMH) in the cholinergic pathways show a stronger correlation with cognitive performance than general WMH in Alzheimer's disease. However, the role of WMH within the cholinergic pathways in cognitive dysfunction has not been investigated in Parkinson's disease (PD). Method The severity of WMH within the cholinergic pathways of PD subgroups with intact cognition (PD-IC, n=44), mild cognitive impairment (PD-MCI, n=87) and dementia (PDD, n=40) were compared using the Cholinergic Pathways Hyperintensities Scale (CHIPS), and the correlation between the CHIPS score and performance on individual tests of cognitive subdomains were analysed. Results The mean CHIPS score was significantly higher in patients with PDD compared with those with PD-IC (p=0.03) or PD-MCI (p=0.015). The CHIPS score in patients with PD was negatively correlated with general cognition assessed using the Mini-Mental State Examination (r=−0.28, p<0.001) and positively with the Unified Parkinson's Disease Rating Scale motor score (r=0.24, p=0.002). The CHIPS score showed a significant correlation with cognitive performance on individual cognitive subdomains and had the highest independent correlations with contrasting programme (β=−0.33, p<0.001) and forward digit span (β=−0.17, p=0.04). Conclusions This study demonstrated that the burden of WMH within cholinergic pathways was significantly higher in patients with PDD relative to other groups, and that cholinergic WMH was significantly correlated with a decline in frontal executive function and attention.
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DOI: 10.1136/jnnp-2011-300872
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However, the role of WMH within the cholinergic pathways in cognitive dysfunction has not been investigated in Parkinson's disease (PD). Method The severity of WMH within the cholinergic pathways of PD subgroups with intact cognition (PD-IC, n=44), mild cognitive impairment (PD-MCI, n=87) and dementia (PDD, n=40) were compared using the Cholinergic Pathways Hyperintensities Scale (CHIPS), and the correlation between the CHIPS score and performance on individual tests of cognitive subdomains were analysed. Results The mean CHIPS score was significantly higher in patients with PDD compared with those with PD-IC (p=0.03) or PD-MCI (p=0.015). The CHIPS score in patients with PD was negatively correlated with general cognition assessed using the Mini-Mental State Examination (r=−0.28, p<0.001) and positively with the Unified Parkinson's Disease Rating Scale motor score (r=0.24, p=0.002). The CHIPS score showed a significant correlation with cognitive performance on individual cognitive subdomains and had the highest independent correlations with contrasting programme (β=−0.33, p<0.001) and forward digit span (β=−0.17, p=0.04). Conclusions This study demonstrated that the burden of WMH within cholinergic pathways was significantly higher in patients with PDD relative to other groups, and that cholinergic WMH was significantly correlated with a decline in frontal executive function and attention.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>Niger</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Shin, Jaeseung" sort="Shin, Jaeseung" uniqKey="Shin J" first="Jaeseung" last="Shin">Jaeseung Shin</name></noRegion><name sortKey="Choi, Sungeun" sort="Choi, Sungeun" uniqKey="Choi S" first="Sungeun" last="Choi">Sungeun Choi</name><name sortKey="Lee, Hye Sun" sort="Lee, Hye Sun" uniqKey="Lee H" first="Hye Sun" last="Lee">Hye Sun Lee</name><name sortKey="Lee, Ji E" sort="Lee, Ji E" uniqKey="Lee J" first="Ji E" last="Lee">Ji E. 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